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GSK3α/β Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72081

  • Amount:

    100ul

  • Molecular Weight:

    (Da)：50981

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat;Drosophila

  • Purification:

    ：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    ：The antiserum was produced against synthesized peptide derived from human GSK3 alpha/beta. AA range:246-295

  • Source:

    ：Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using GSK3α/β Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    ：GSK3A/GSK3B

  • Dilution:

    ：Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    ：Glycogen synthase kinase-3 alpha/beta

  • Human Gene Id:

    ：2931

  • Human Swiss Prot No:

    ：P49840/P49841

  • Mouse Gene Id:

    ：606496/56637

  • Rat Gene Id:

    ：50686/84027

  • Rat Swiss Prot No:

    ：P18265/P18266

  • Specificity:

    ：GSK3α/β Polyclonal Antibody detects endogenous levels of GSK3α/β protein.

  • Formulation:

    ：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    ：1 mg/ml

  • Storage Stability:

    ：-20°C/1 year

  • Other Name:

    ：GSK3A; Glycogen synthase kinase-3 alpha; GSK-3 alpha; Serine/threonine-protein kinase GSK3A; GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B

  • Observed Band(KD):

    ：51,46

  • Background:

    ：glycogen synthase kinase 3 alpha(GSK3A) Homo sapiens This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011],

  • Function:

    ：catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,function:Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer.,

  • Subcellular Location:

    ：mitochondrion,cytosol,beta-catenin destruction complex,postsynapse,

  • Expression:

    ：Brain,Eye,Foreskin,Lung,Pancreas,Platelet,Testis,

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using GSK3 alpha/beta Antibody. The picture on the right is blocked with the synthesized peptide.

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