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GRK 5 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72070

  • Amount:

    100ul

  • Molecular Weight:

    67787Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GRK5. AA range:351-400

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using GRK 5 Polyclonal Antibody

  • Gene Name:

    GRK5

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    G protein-coupled receptor kinase 5

  • Human Gene Id:

    2869

  • Human Swiss Prot No:

    P34947

  • Mouse Gene Id:

    14773

  • Mouse Swiss Prot No:

    Q8VEB1

  • Rat Gene Id:

    59075

  • Rat Swiss Prot No:

    Q62833

  • Specificity:

    GRK 5 Polyclonal Antibody detects endogenous levels of GRK 5 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    GRK5; GPRK5; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5

  • Observed Band(KD):

    68

  • Background:

    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Specifically phosphorylates the activated forms of G protein-coupled receptors.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney.,

  • Subcellular Location:

    Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion.

  • Expression:

    Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney.

  • Western Blot analysis of COLO205 cells using GRK 5 Polyclonal Antibody

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Catalog Number

  • Amount:100ul
  • Price:225$

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GRK 5 Polyclonal Antibody | EnoGene Biotech Co. Ltd