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GRK 2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72067

  • Amount:

    100ul

  • Molecular Weight:

    9574Da

  • Reactivity:

    Human,Mouse,Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GRK2. AA range:640-689

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of Hela cells using GRK 2 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    ADRBK1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications

  • Protein Name:

    Beta-adrenergic receptor kinase 1

  • Human Gene Id:

    156

  • Human Swiss Prot No:

    P25098

  • Specificity:

    GRK 2 Polyclonal Antibody detects endogenous levels of GRK 2 protein

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ADRBK1; BARK; BARK1; GRK2; Beta-adrenergic receptor kinase 1; Beta-ARK-1; G-protein coupled receptor kinase 2

  • Observed Band(KD):

    80

  • Background:

    G protein-coupled receptor kinase 2(GRK2) Homo sapiens The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]

  • Function:

    catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.,online information:Beta adrenergic receptor kinase entry,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5.,tissue specificity:Expressed in peripheral blood leukocytes

  • Subcellular Location:

    cytoplasm,cytosol,plasma membrane,membrane,primary cilium

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using GRK2 Antibody. The picture on the right is blocked with the synthesized peptide

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Catalog Number

  • Amount:100ul
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GRK 2 Polyclonal Antibody | EnoGene Biotech Co. Ltd