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GRK 1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72063

  • Amount:

    100ul

  • Molecular Weight:

    63526Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GRK1. AA range:6-55

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using GRK 1 Polyclonal Antibody

  • Gene Name:

    GRK1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Rhodopsin kinase

  • Human Gene Id:

    6011

  • Human Swiss Prot No:

    Q15835

  • Mouse Swiss Prot No:

    Q9WVL4

  • Rat Gene Id:

    81760

  • Rat Swiss Prot No:

    Q63651

  • Specificity:

    GRK 1 Polyclonal Antibody detects endogenous levels of GRK 1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    GRK1; RHOK; Rhodopsin kinase; RK; G protein-coupled receptor kinase 1

  • Observed Band(KD):

    63

  • Background:

    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.,disease:Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type (CSNBO) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.,function:Phosphorylates rhodopsin thereby initiating its deactivation.,online information:Retina International's Scientific Newsletter,PTM:Autophosphorylated.,PTM:Farnesylation is required for full activity.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:R

  • Subcellular Location:

    Membrane ; Lipid-anchor . Cell projection, cilium, photoreceptor outer segment . Subcellular location is not affected by light or dark conditions. .

  • Expression:

    Retinal-specific. Expressed in rods and cones cells.

  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GRK1 Antibody. The picture on the right is blocked with the synthesized peptide.

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