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GRB14 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72055

  • Amount:

    100ul

  • Molecular Weight:

    60988Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GRB14. AA range:81-130

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using GRB14 Polyclonal Antibody

  • Gene Name:

    GRB14

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Growth factor receptor-bound protein 14

  • Human Gene Id:

    2888

  • Human Swiss Prot No:

    Q14449

  • Mouse Gene Id:

    50915

  • Mouse Swiss Prot No:

    Q9JLM9

  • Rat Gene Id:

    58844

  • Rat Swiss Prot No:

    O88900

  • Specificity:

    GRB14 Polyclonal Antibody detects endogenous levels of GRB14 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    GRB14; Growth factor receptor-bound protein 14; GRB14 adapter protein

  • Observed Band(KD):

    61

  • Background:

    The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

  • Function:

    function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain.,PTM:Phosphorylated on serine residues.,similarity:Belongs to the GRB7/10/14 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,subunit:Binds to the ankyrin repeat region of TNKS2 via its N-terminus.,tissue specificity:Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.,

  • Subcellular Location:

    Cytoplasm . Endosome membrane ; Peripheral membrane protein . Upon insulin stimulation, translocates to the plasma membrane. .

  • Expression:

    Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

  • Western blot analysis of lysates from HUVEC, COLO, and MCF-7 cells, using GRB14 Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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GRB14 Polyclonal Antibody | EnoGene Biotech Co. Ltd