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Cell Signal Transduction Research Antibodies
Grap Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight25337Da
Protein NameGRB2-related adapter protein
Human Gene Id10750
Human Swiss Prot NoQ13588
Mouse Gene Id71520
Mouse Swiss Prot NoQ9CX99
SpecificityGrap Polyclonal Antibody detects endogenous levels of Grap protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGRAP; GRB2-related adapter protein
Observed Band(KD)28
Functionfunction:Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.,similarity:Belongs to the GRB2/sem-5/DRK family.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB.,
Subcellular Locationcytoplasm,cytosol,
ExpressionBlood,Brain,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human GRAP. AA range:1-50
Gene NameGRAP
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundGRB2-related adaptor protein(GRAP) Homo sapiens This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012],
Conjugated Antibody
This product is also available conjugated. Format: E20-72052-Conjugate. Price: $485 / Size: 100μl.
E20-72052-FITC$485 / 100μlE20-72052-Biotin$485 / 100μlE20-72052-HRP$485 / 100μlE20-72052-AP$485 / 100μlE20-72052-AF350$485 / 100μlE20-72052-AF405M$485 / 100μlE20-72052-AF488$485 / 100μlE20-72052-AF514$485 / 100μlE20-72052-AF532$485 / 100μlE20-72052-AF555$485 / 100μlE20-72052-AF568$485 / 100μlE20-72052-AF405S$485 / 100μlE20-72052-AF405L$485 / 100μlE20-72052-AF546$485 / 100μlE20-72052-AF594$485 / 100μlE20-72052-AF610$485 / 100μlE20-72052-AF635$485 / 100μlE20-72052-AF647$485 / 100μlE20-72052-AF680$485 / 100μlE20-72052-AF700$485 / 100μlE20-72052-AF750$485 / 100μlE20-72052-AF790$485 / 100μlE20-72052-APC$485 / 100μlE20-72052-PE$485 / 100μlE20-72052-Cy3$485 / 100μlE20-72052-Cy5$485 / 100μlE20-72052-Cy5.5$485 / 100μlE20-72052-Cy7$485 / 100μlE20-72052-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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