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GPR143 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71974Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human GPR143. AA range:151-200Source:
Polyclonal, RabbitGene Name:
GPR143Dilution:
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
- Immunofluorescence analysis of LOVO cells, using GPR143 Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
G protein-coupled receptor 143(GPR143) Homo sapiens This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009],Protein Name:
G-protein coupled receptor 143Human Gene Id:
4935Human Swiss Prot No:
P51810Mouse Gene Id:
18241Mouse Swiss Prot No:
P70259Specificity:
GPR143 Polyclonal Antibody detects endogenous levels of GPR143 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
GPR143; OA1; G-protein coupled receptor 143; Ocular albinism type 1 proteinMolecularWeight(Da):
43878Function:
disease:Defects in GPR143 are the cause of ocular albinism type 1 (OA1) [MIM:300500]; also known as Nettleship-Falls type ocular albinism. OA1 is an X-linked disorder characterized by severe impairment of visual acuity, retinal hypopigmentation and the presence of macromelanosomes.,function:Not known; binds heterotrimeric G proteins.,online information:GPR143 mutations,online information:Retina International's Scientific Newsletter,similarity:Belongs to the G-protein coupled receptor OA family.,subcellular location:Targeted to intracellular organelles, namely the melanosomes in pigment cells.,tissue specificity:Exclusively expressed in pigment cells.,Subcellular Location:
cytoplasm,lysosomal membrane,Golgi apparatus,plasma membrane,membrane,integral component of membrane,apical plasma membrane,melanosome membrane,melanosome,Expression:
Melanocyte,Retina,Skin,
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