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GPR120 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71964

  • Amount:

    100ul

  • Molecular Weight:

    42241Da

  • Applications:

    WB;IF/ICC;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GPR120. AA range:221-270

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using GPR120 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    O3FAR1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Omega-3 fatty acid receptor 1

  • Human Gene Id:

    338557

  • Human Swiss Prot No:

    Q5NUL3

  • Mouse Gene Id:

    107221

  • Mouse Swiss Prot No:

    Q7TMA4

  • Rat Gene Id:

    294075

  • Rat Swiss Prot No:

    Q2AC31

  • Specificity:

    GPR120 Polyclonal Antibody detects endogenous levels of GPR120 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    O3FAR1; GPR120; GPR129; PGR4; Omega-3 fatty acid receptor 1; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4

  • Observed Band(KD):

    38

  • Background:

    This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],

  • Function:

    function:Receptor for unsaturated long-chain free fatty acid (FAA). Binding of the ligand promotes the secretion of glucagon-like peptide-1 from the gastro-intestinal tract.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Abundant expression in the intestinal tract.,

  • Subcellular Location:

    [Isoform 1]: Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Sorted to late endosome/lysosome compartments upon internalization. .; [Isoform 2]: Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Cell projection, cilium membrane ; Multi-pass membrane protein . Sorted to late endosome/lysosome compartments upon internalization (PubMed:22282525). Specifically localizes to the primary cilium of undifferentiated adipocytes. Ciliary trafficking is TULP3-dependent. As the cilium is lost during adipogenesis, moves to the plasma membrane (Probable). .

  • Expression:

    [Isoform 2]: The predominant isoform in human tissues. Expressed in adipose tissue, pancreatic islets, lung and brain. Expressed in alpha cells of pancreatic islets (PubMed:24742677). Expressed in primary cilia of perivascular preadipocytes of white adipose tissue (at protein level) (PubMed:31761534). ; Abundant expression in the intestinal tract. Expressed in colonic intraepithelial neuroendocrine cells.

  • Western Blot analysis of HEPG2-UV cells using GPR120 Polyclonal Antibody diluted at 1:500

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