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GK1/3 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71911

  • Amount:

    100ul

  • Molecular Weight:

    60570DaObserved Band:61KD

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GK3. AA range:21-70

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of Jurkat cells using GK2 Polyclonal Antibody

  • Gene Name:

    GK/GK3P

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Putative glycerol kinase 3

  • Human Gene Id:

    2713

  • Human Swiss Prot No:

    P32189/Q14409

  • Specificity:

    GK1/3 Polyclonal Antibody detects endogenous levels of GK1/3 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    GK; Glycerol kinase; GK; Glycerokinase; ATP:glycerol 3-phosphotransferase; GK3P; GKP3; GKTB; Putative glycerol kinase 3; GK 3; Glycerokinase 3; ATP:glycerol 3-phosphotransferase 3; Glycerol kinase; testis specific 1

  • Background:

    The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011],

  • Function:

    catalytic activity:ATP + glycerol = ADP + sn-glycerol 3-phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in GK are the cause of GK deficiency (GKD) [MIM:307030]. This disease can be either symptomatic with episodic metabolic and CNS decompensation or asymptomatic with hyperglycerolemia and hyperglyceroluria only.,function:Key enzyme in the regulation of glycerol uptake and metabolism.,pathway:Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.,similarity:Belongs to the FGGY kinase family.,subcellular location:In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.,tissue specificity:Highly expressed in the liver, kidney and testis

  • Subcellular Location:

    Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.

  • Expression:

    Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver.

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Catalog Number

  • Amount:100ul
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GK1/3 Polyclonal Antibody | EnoGene Biotech Co. Ltd