Product Information
Protein NameGrowth hormone-releasing hormone receptor
Human Gene Id2692
Human Swiss Prot NoQ02643
SpecificityGHRH-R Polyclonal Antibody detects endogenous levels of GHRH-R protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGHRHR; Growth hormone-releasing hormone receptor; GHRH receptor; Growth hormone-releasing factor receptor; GRF receptor; GRFR
MolecularWeight(Da)47402
Observed Band(KD)47
Functiondisease:Defects in GHRHR are a cause of isolated growth hormone deficiency type IB (IGHD IB) [MIM:262400]; also known as pituitary dwarfism I. IGHD IB is an autosomal recessive deficiency of GH which cause short stature.,function:Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Pituitary gland.,
Subcellular Locationnuclear inner membrane,nuclear outer membrane,cytoplasm,plasma membrane,cell surface,integral component of membrane,nuclear matrix,secretory granule,sarcolemma,
ExpressionPituitary,Pituitary gland,Prostate,
Backgroundgrowth hormone releasing hormone receptor(GHRHR) Homo sapiens This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010],