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GCS-β-1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71886Amount:
100ulMolecular Weight:
70514DaObserved Band:70KDApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Guanylate Cyclase beta. AA range:10-59Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using GCS-β-1 Polyclonal Antibody
Gene Name:
GUCY1B3Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.Protein Name:
Guanylate cyclase soluble subunit beta-1Human Gene Id:
2983Human Swiss Prot No:
Q02153Mouse Gene Id:
54195Mouse Swiss Prot No:
O54865Rat Gene Id:
25202Rat Swiss Prot No:
P20595Specificity:
GCS-β-1 Polyclonal Antibody detects endogenous levels of GCS-β-1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
GUCY1B3; GUC1B3; GUCSB3; GUCY1B1; Guanylate cyclase soluble subunit beta-1; GCS-beta-1; Guanylate cyclase soluble subunit beta-3; GCS-beta-3; Soluble guanylate cyclase small subunitBackground:
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],Function:
catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,cofactor:Binds 1 or 2 heme groups per heterodimer.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain.,Subcellular Location:
Cytoplasm .Expression:
Detected in brain cortex and cerebellum (at protein level).
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