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GCSm-γ Polyclonal Antibody
Datasheet
Catalog Number:
E20-71884Amount:
100ulMolecular Weight:
30727DaObserved Band:31KDApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;Mouse;Rat;MonkeyPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human GCSm-gamma. AA range:42-91Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using GCSm-γ Polyclonal Antibody diluted at 1:1000
Gene Name:
GCLMDilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.Protein Name:
Glutamate--cysteine ligase regulatory subunitHuman Gene Id:
2730Human Swiss Prot No:
P48507Mouse Gene Id:
14630Mouse Swiss Prot No:
O09172Rat Gene Id:
29739Rat Swiss Prot No:
P48508Specificity:
GCSm-γ Polyclonal Antibody detects endogenous levels of GCSm-γ protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
GCLM; GLCLR; Glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunitBackground:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],Function:
pathway:Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.,similarity:Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.,subunit:Heterodimer of a catalytic heavy chain and a regulatory light chain.,tissue specificity:In all tissues examined. Highest levels in skeletal muscle.,Subcellular Location:
cytosol,glutamate-cysteine ligase complex,Expression:
In all tissues examined. Highest levels in skeletal muscle.
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