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GATA-1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71858Amount:
100ulMolecular Weight:
42751DaApplications:
：WB;IHC-p;IP;IF/ICC;ELISAReactivity:
：Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human GATA1. AA range:277-326Source:
Polyclonal, Rabbit,IgG
- Western blot analysis of lysates from COLO cells, using GATA1 Antibody. The lane on the right is blocked with the synthesized peptide.
Gene Name:
GATA1Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.Protein Name:
Erythroid transcription factorHuman Gene Id:
2623Human Swiss Prot No:
P15976Mouse Gene Id:
14460Mouse Swiss Prot No:
P17679Rat Gene Id:
1.00911e+008Rat Swiss Prot No:
P43429Specificity:
GATA-1 Polyclonal Antibody detects endogenous levels of GATA-1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
GATA1; ERYF1; GF1; Erythroid transcription factor; Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding proteinObserved Band(KD):
43Background:
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008],Function:
disease:Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.,disease:Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also called thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. The disease consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor.,domain:The two fingers are functionally distinct and cooperate to achieSubcellular Location:
Nucleus.Expression:
Erythrocytes.
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