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GAP-43 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71849

  • Amount:

    100ul

  • Molecular Weight:

    24803Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GAP43. AA range:8-57

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using GAP-43 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    GAP43

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Neuromodulin

  • Human Gene Id:

    2596

  • Human Swiss Prot No:

    P17677

  • Mouse Gene Id:

    14432

  • Mouse Swiss Prot No:

    P06837

  • Rat Gene Id:

    29423

  • Rat Swiss Prot No:

    P07936

  • Specificity:

    GAP-43 Polyclonal Antibody detects endogenous levels of GAP-43 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    GAP43; Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46

  • Observed Band(KD):

    43

  • Background:

    The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

  • Function:

    function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.,

  • Subcellular Location:

    Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. .

  • Expression:

    Alzheimer cortex,Brain,Subthalamic nucleus,

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