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Galectin-9 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71841

  • Amount:

    100ul

  • Molecular Weight:

    39518Da

  • Applications:

    WB;IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human LEG9. AA range:51-100

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of HepG2 cells using Galectin-9 Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    LGALS9

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Galectin-9

  • Human Gene Id:

    3965

  • Human Swiss Prot No:

    O00182

  • Mouse Gene Id:

    16859

  • Mouse Swiss Prot No:

    O08573

  • Rat Gene Id:

    25476

  • Rat Swiss Prot No:

    P97840

  • Specificity:

    Galectin-9 Polyclonal Antibody detects endogenous levels of Galectin-9 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    LGALS9; Galectin-9; Gal-9; Ecalectin; Tumor antigen HOM-HD-21

  • Observed Band(KD):

    40

  • Background:

    The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008],

  • Function:

    alternative products:Additional isoforms seem to exist,domain:Contains two homologous but distinct carbohydrate-binding domains.,function:Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. The isoform Short acts as an eosinophil chemoattractant. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death.,online information:Galectin-9,similarity:Contains 2 galectin domains.,subcellular location:May also be secreted by a non-classical secretory pathway.,subunit:Monomer.,tissue specificity:Peripheral blood leukocytes and lymphatic tissues. Overexpressed in Hodgkin's disease tissue.,

  • Subcellular Location:

    Cytoplasm . Nucleus . Secreted . May also be secreted by a non-classical secretory pathway (By similarity). Secreted by mesenchymal stromal cells upon IFNG stimulation (PubMed:23817958). .; [Isoform 2]: Secreted .; [Isoform 3]: Secreted .

  • Expression:

    Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696). Isoform 4 decreases in pathological pregnancy (PubMed:23242525).

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Galectin-9 Polyclonal Antibody | EnoGene Biotech Co. Ltd