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Gads Polyclonal Antibody
Datasheet
Catalog Number:
E20-71833Amount:
100ulMolecular Weight:
37909DaApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human GRAP2. AA range:121-170Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using Gads Polyclonal Antibody
Gene Name:
GRAP2Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.Protein Name:
GRB2-related adapter protein 2Human Gene Id:
9402Human Swiss Prot No:
O75791Mouse Swiss Prot No:
O89100Specificity:
Gads Polyclonal Antibody detects endogenous levels of Gads protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
GRAP2; GADS; GRB2L; GRID; GRB2-related adapter protein 2; Adapter protein GRID; GRB-2-like protein; GRB2L; GRBLG; GRBX; Grf40 adapter protein; Grf-40; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpObserved Band(KD):
38Background:
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],Function:
function:Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.,similarity:Belongs to the GRB2/sem-5/DRK family.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB.,Subcellular Location:
Nucleus . Cytoplasm . Endosome .Expression:
Blood,Lung,Platelet,Spleen,T-cell,Thymus,
- Western Blot analysis of HuvEc cells using Gads Polyclonal Antibody
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