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GABAA Rα4 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71822

  • Amount:

    100ul

  • Molecular Weight:

    61640Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GABRA4. AA range:81-130

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using GABAA Rα4 Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    GABRA4

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Gamma-aminobutyric acid receptor subunit alpha-4

  • Human Gene Id:

    2557

  • Human Swiss Prot No:

    P48169

  • Mouse Gene Id:

    14397

  • Mouse Swiss Prot No:

    Q9D6F4

  • Rat Gene Id:

    140675

  • Rat Swiss Prot No:

    P28471

  • Specificity:

    GABAA Rα4 Polyclonal Antibody detects endogenous levels of GABAA Rα4 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    GABRA4; Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4

  • Observed Band(KD):

    60

  • Background:

    Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],

  • Function:

    function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,induction:The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,

  • Subcellular Location:

    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

  • Expression:

    Brain,Brain cortex,

  • Western blot analysis of GABRA4 Antibody. The lane on the right is blocked with the GABRA4 peptide.

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Catalog Number

  • Amount:100ul
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