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Gab 2 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71816Amount:
100ulMolecular Weight:
74458DaApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
Synthesized peptide derived from Gab 2 . at AA range: 210-290Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using Gab 2 Polyclonal Antibody
Gene Name:
GAB2Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.Protein Name:
GRB2-associated-binding protein 2Human Gene Id:
9846Human Swiss Prot No:
Q9UQC2Mouse Swiss Prot No:
Q9Z1S8Rat Gene Id:
84477Rat Swiss Prot No:
Q9EQH1Specificity:
Gab 2 Polyclonal Antibody detects endogenous levels of Gab 2 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
GAB2; KIAA0571; GRB2-associated-binding protein 2; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100Observed Band(KD):
75Background:
GRB2 associated binding protein 2(GAB2) Homo sapiens This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009],Function:
PTM:Dephosphorylated by PTPN11.,PTM:Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2, PI-3 kinase and with other SH2-containing proteins.,Subcellular Location:
Cytoplasm . Cell membrane .Expression:
Brain,Clones donated by Kazusa DNA Research Inst.,
- Western Blot analysis of K562 cells using Gab 2 Polyclonal Antibody
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