World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
FRS2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight57528Da
Protein NameFibroblast growth factor receptor substrate 2
Human Gene Id10818
Human Swiss Prot NoQ8WU20
Mouse Gene Id327826
Mouse Swiss Prot NoQ8C180
SpecificityFRS2 Polyclonal Antibody detects endogenous levels of FRS2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameFRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1
Observed Band(KD)65
Functionfunction:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and t
Subcellular Locationcytoplasm,endosome,plasma membrane,integral component of plasma membrane,cell-cell junction,membrane,
ExpressionHippocampus,Placenta,Uterus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human FRS2. AA range:162-211
Gene NameFRS2
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Backgroundfunction:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,
Conjugated Antibody
This product is also available conjugated. Format: E20-71792-Conjugate. Price: $485 / Size: 100μl.
E20-71792-FITC$485 / 100μlE20-71792-Biotin$485 / 100μlE20-71792-HRP$485 / 100μlE20-71792-AP$485 / 100μlE20-71792-AF350$485 / 100μlE20-71792-AF405M$485 / 100μlE20-71792-AF488$485 / 100μlE20-71792-AF514$485 / 100μlE20-71792-AF532$485 / 100μlE20-71792-AF555$485 / 100μlE20-71792-AF568$485 / 100μlE20-71792-AF405S$485 / 100μlE20-71792-AF405L$485 / 100μlE20-71792-AF546$485 / 100μlE20-71792-AF594$485 / 100μlE20-71792-AF610$485 / 100μlE20-71792-AF635$485 / 100μlE20-71792-AF647$485 / 100μlE20-71792-AF680$485 / 100μlE20-71792-AF700$485 / 100μlE20-71792-AF750$485 / 100μlE20-71792-AF790$485 / 100μlE20-71792-APC$485 / 100μlE20-71792-PE$485 / 100μlE20-71792-Cy3$485 / 100μlE20-71792-Cy5$485 / 100μlE20-71792-Cy5.5$485 / 100μlE20-71792-Cy7$485 / 100μlE20-71792-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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