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Frizzled-3 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71777

  • Amount:

    100ul

  • Molecular Weight:

    76263DaObserved Band:76KD

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human FZD3. AA range:141-190

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Frizzled-3 Polyclonal Antibody

  • Gene Name:

    FZD3

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Frizzled-3

  • Human Gene Id:

    7976

  • Human Swiss Prot No:

    Q9NPG1

  • Mouse Gene Id:

    14365

  • Mouse Swiss Prot No:

    Q61086

  • Specificity:

    Frizzled-3 Polyclonal Antibody detects endogenous levels of Frizzled-3 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    FZD3; Frizzled-3; Fz-3; hFz3

  • Background:

    frizzled class receptor 3(FZD3) Homo sapiens This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010],

  • Function:

    domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphog

  • Subcellular Location:

    Membrane; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein . Cell surface . Apical cell membrane ; Multi-pass membrane protein. Colocalizes with FZD6 at the apical face of the cell (By similarity). .

  • Expression:

    Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.

  • Western Blot analysis of RAW264.7 cells using Frizzled-3 Polyclonal Antibody

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