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Frizzled-1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71773

  • Amount:

    100ul

  • Molecular Weight:

    71158DaObserved Band:71KD

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human FZD1. AA range:15-64

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Frizzled-1 Polyclonal Antibody

  • Gene Name:

    FZD1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Frizzled-1

  • Human Gene Id:

    8321

  • Human Swiss Prot No:

    Q9UP38

  • Mouse Swiss Prot No:

    O70421

  • Specificity:

    Frizzled-1 Polyclonal Antibody detects endogenous levels of Frizzled-1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    FZD1; Frizzled-1; Fz-1; hFz1; FzE1

  • Background:

    frizzled class receptor 1(FZD1) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008],

  • Function:

    domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphog

  • Subcellular Location:

    Cell membrane ; Multi-pass membrane protein .

  • Expression:

    Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.

  • Western blot analysis of lysates from HeLa and COLO205 cells, using FZD1 Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

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Frizzled-1 Polyclonal Antibody | EnoGene Biotech Co. Ltd