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FoxO4 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71766Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human AFX1. AA range:228-277Source:
Polyclonal, RabbitGene Name:
FOXO4Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.Background:
forkhead box O4(FOXO4) Homo sapiens This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010],Protein Name:
Forkhead box protein O4Human Gene Id:
4303Human Swiss Prot No:
P98177Mouse Gene Id:
54601Mouse Swiss Prot No:
Q9WVH3Specificity:
FoxO4 Polyclonal Antibody detects endogenous levels of FoxO4 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
FOXO4; AFX; AFX1; MLLT7; Forkhead box protein O4; Fork head domain transcription factor AFX1MolecularWeight(Da):
53684Observed Band(KD):
54Function:
disease:A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein.,function:Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.,pharmaceutical:A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity.,PTM:Acetylation by CBP, which is induced by peroxidase stress, inhibits transcriptional activity. DeaSubcellular Location:
nucleus,nucleoplasm,cytoplasm,cytosol,Expression:
Blood,Bone marrow,
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Catalog Number
- Amount:100ul
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