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Fli-1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71720

  • Amount:

    100ul

  • Molecular Weight:

    50982Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human FLI1. AA range:291-340

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of 3T3 cells using Fli-1 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit

  • Gene Name:

    FLI1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Friend leukemia integration 1 transcription factor

  • Human Gene Id:

    2313

  • Human Swiss Prot No:

    Q01543

  • Mouse Gene Id:

    14247

  • Mouse Swiss Prot No:

    P26323

  • Specificity:

    Fli-1 Polyclonal Antibody detects endogenous levels of Fli-1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    FLI1; Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB

  • Observed Band(KD):

    50

  • Background:

    Fli-1 proto-oncogene, ETS transcription factor(FLI1) Homo sapiens This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

  • Function:

    disease:A chromosomal aberration involving FLI1 is a cause of Ewing sarcoma [MIM:133450]. Translocation t(11;22)(q24;q12) with EWS.,function:Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.,miscellaneous:Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Can form homodimers or heterodimers with ETV6/TEL1.,

  • Subcellular Location:

    Nucleus .

  • Expression:

    Blood,Bone marrow,Lymph,Placenta,

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