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Fatty Acid Synthase Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71683

  • Amount:

    100ul

  • Molecular Weight:

    273400Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Fatty Acid Synthase. AA range:1478-1527

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Fatty Acid Synthase Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    FASN

  • Dilution:

    IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Fatty acid synthase

  • Human Gene Id:

    2194

  • Human Swiss Prot No:

    P49327

  • Mouse Swiss Prot No:

    P19096

  • Specificity:

    Fatty Acid Synthase Polyclonal Antibody detects endogenous levels of Fatty Acid Synthase protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    FASN; FAS; Fatty acid synthase

  • Observed Band(KD):

    273

  • Background:

    fatty acid synthase(FASN) Homo sapiens The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH.,catalytic activity:(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] = hexadec-2-enoyl-[acyl-carrier-protein] + H(2)O.,catalytic activity:Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].,catalytic activity:Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+).,catalytic activity:Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].,catalytic activity:Acyl-[acyl-carrier-protein] + NADP(+) = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH.,catalytic activity:Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].,catalytic activity:Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate.,functi

  • Subcellular Location:

    Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

  • Expression:

    Ubiquitous. Prominent expression in brain, lung, liver and mammary gland.

  • Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:100(4° overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).

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