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FAST Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71678

  • Amount:

    100ul

  • Molecular Weight:

    61104Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human FAST. AA range:361-410

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using FAST Polyclonal Antibody

  • Gene Name:

    FASTK

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Fas-activated serine/threonine kinase

  • Human Gene Id:

    10922

  • Human Swiss Prot No:

    Q14296

  • Mouse Swiss Prot No:

    Q9JIX9

  • Specificity:

    FAST Polyclonal Antibody detects endogenous levels of FAST protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    FASTK; Fas-activated serine/threonine kinase; FAST kinase

  • Observed Band(KD):

    61

  • Background:

    Fas activated serine/threonine kinase(FASTK) Homo sapiens The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein].,function:Fas-mediated apoptosis is characterized by FASTK-dephosphorylation and TIA-1-phosphorylation. Both are activated and FASTK-mediated TIA-1 activation play a key role in apoptosis.,PTM:Phosphorylated on serine/threonine.,similarity:Belongs to the FAST protein kinase family.,similarity:Contains 1 RAP domain.,subunit:Interacts with TIA-1.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,

  • Subcellular Location:

    [Isoform 4]: Mitochondrion matrix . Colocalizes with mitochondrial RNA granules. .

  • Expression:

    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

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Catalog Number

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