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ERα Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71635

  • Amount:

    100ul

  • Molecular Weight:

    66216(Da) Observed Band(KD)66

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Estrogen Receptor-alpha. AA range:71-120

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ESR1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Estrogen Receptor-alpha Antibody. The picture on the right is blocked with the synthesized peptide.

  • Protein Name:

    Estrogen receptor

  • Human Gene Id:

    2099

  • Human Swiss Prot No:

    P03372

  • Mouse Gene Id:

    13982

  • Mouse Swiss Prot No:

    P19785

  • Rat Gene Id:

    24890

  • Rat Swiss Prot No:

    P06211

  • Specificity:

    ERα Polyclonal Antibody detects endogenous levels of ERα protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ESR1; ESR; NR3A1; Estrogen receptor; ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

  • Background:

    estrogen receptor 1(ESR1) Homo sapiens This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014],

  • Function:

    domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.,online information:Estrogen receptor entry,polymorphism:Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.,PTM:Glycosylated; contains N-acetylglucosamine, probably O-linked.,PTM:Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcri

  • Subcellular Location:

    nuclear chromatin,nucleus,nucleoplasm,cytoplasm,Golgi apparatus,plasma membrane,membrane,integral component of membrane,transcriptionally active chromatin,

  • Expression:

    Brain,Breast,Breast adenocarcinoma,Breast cancer,Mammary carcinoma,Mammary gland,PC

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Catalog Number

  • Amount:100ul
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