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ERdj3 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71616

  • Amount:

    100ul

  • Molecular Weight:

    40514Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human DNAJB11. AA range:31-80

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of MCF7 cells using ERdj3 Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    DNAJB11

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    DnaJ homolog subfamily B member 11

  • Human Gene Id:

    51726

  • Human Swiss Prot No:

    Q9UBS4

  • Mouse Gene Id:

    67838

  • Mouse Swiss Prot No:

    Q99KV1

  • Rat Gene Id:

    360734

  • Rat Swiss Prot No:

    Q6TUG0

  • Specificity:

    ERdj3 Polyclonal Antibody detects endogenous levels of ERdj3 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    DNAJB11; EDJ; ERJ3; HDJ9; PSEC0121; DnaJ homolog subfamily B member 11; APOBEC1-binding protein 2; ABBP-2; DnaJ protein homolog 9; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; ER-associated dnaJ protein 3; ERdj3; ERj3p; HEDJ; Human

  • Observed Band(KD):

    40

  • Background:

    DnaJ heat shock protein family (Hsp40) member B11(DNAJB11) Homo sapiens This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014],

  • Function:

    caution:PubMed:11584023 reported a cytosolic, as well as nuclear subcellular location. This result was obtained using an N-terminally GFP-tagged construct which most probably affected signal peptide-driven targeting to the ER. As a consequence, the in vivo revelance of the observed interaction with APOBEC1, a nuclear protein, is dubious. This holds true for the interaction with PWP1.,function:Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.,induction:By ER stress-inducing agents, such as thapsigargin and tunicamycin.,PTM:Contains high-mannose Endo H-sensitive carbohydrates.,PTM:Cys-169, Cys-171, Cys-193 and Cys-196

  • Subcellular Location:

    Endoplasmic reticulum lumen . Associated with the ER membrane in a C-terminally epitope-tagged construct.

  • Expression:

    Widely expressed.

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Catalog Number

  • Amount:100ul
  • Price:225$

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ERdj3 Polyclonal Antibody | EnoGene Biotech Co. Ltd