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ERCC4 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71615

  • Amount:

    100ul

  • Molecular Weight:

    103289Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human XPF. AA range:801-850

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of 293 cells using ERCC4 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit

  • Gene Name:

    ERCC4

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    DNA repair endonuclease XPF

  • Human Gene Id:

    2072

  • Human Swiss Prot No:

    Q92889

  • Mouse Gene Id:

    50505

  • Mouse Swiss Prot No:

    Q9QZD4

  • Specificity:

    ERCC4 Polyclonal Antibody detects endogenous levels of ERCC4 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ERCC4; ERCC11; XPF; DNA repair endonuclease XPF; DNA excision repair protein ERCC-4; DNA repair protein complementing XP-F cells; Xeroderma pigmentosum group F-complementing protein

  • Observed Band(KD):

    103

  • Background:

    ERCC excision repair 4, endonuclease catalytic subunit(ERCC4) Homo sapiens The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009],

  • Function:

    cofactor:Magnesium.,disease:Defects in ERCC4 are a cause of XFE progeroid syndrome [MIM:610965]. This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly.,disease:Defects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F) [MIM:278760]; also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities.,function:Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.,similarity:Belongs to the XPF family.,subunit:Heterodimer composed of ERCC1 and XPF/ERCC4. Interacts with EME1.,

  • Subcellular Location:

    Nucleus . Chromosome . Localizes to sites of DNA damage. .

  • Expression:

    Epithelium,Fibroblast,

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Catalog Number

  • Amount:100ul
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ERCC4 Polyclonal Antibody | EnoGene Biotech Co. Ltd