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ErbB-4 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71613

  • Amount:

    100ul

  • Molecular Weight:

    146808(DA)

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human HER4. AA range:1250-1299

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ERBB4

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Immunofluorescence analysis of HepG2 cells, using HER4 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Protein Name:

    Receptor tyrosine-protein kinase erbB-4

  • Human Gene Id:

    2066

  • Human Swiss Prot No:

    Q15303

  • Mouse Gene Id:

    13869

  • Mouse Swiss Prot No:

    Q61527

  • Rat Gene Id:

    59323

  • Rat Swiss Prot No:

    Q62956

  • Specificity:

    ErbB-4 Polyclonal Antibody detects endogenous levels of ErbB-4 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ERBB4; HER4; Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4

  • Background:

    erb-b2 receptor tyrosine kinase 4(ERBB4) Homo sapiens This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:The WW-binding motifs mediate interaction with WWOX.,function:Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin.,PTM:Isoform JM-A is processed but not isoform JM-B. So, they respectively represent cleavable and non-cleavable forms of the receptor.,PTM:Ligand-binding increases phosphorylation on tyrosine residues.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer or heterodimer with each of the other ERBB receptors (Potential). Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SN

  • Subcellular Location:

    extracellular region,nucleus,nucleoplasm,mitochondrion,mitochondrial matrix,cytosol,plasma membrane,integral component of membrane,basolateral plasma membrane,receptor complex,

  • Expression:

    Brain,Fetal brain,Mammary carcinoma,

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Catalog Number

  • Amount:100ul
  • Price:225$

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ErbB-4 Polyclonal Antibody | EnoGene Biotech Co. Ltd