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ERAB Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71605

  • Amount:

    100ul

  • Molecular Weight:

    26923Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat;Monkey

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ERAB. AA range:111-160

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using ERAB Polyclonal Antibody

  • Gene Name:

    HSD17B10

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    3-hydroxyacyl-CoA dehydrogenase type-2

  • Human Gene Id:

    3028

  • Human Swiss Prot No:

    Q99714

  • Mouse Swiss Prot No:

    O08756

  • Rat Gene Id:

    63864

  • Rat Swiss Prot No:

    O70351

  • Specificity:

    ERAB Polyclonal Antibody detects endogenous levels of ERAB protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    HSD17B10; ERAB; HADH2; MRPP2; SCHAD; XH98G2; 3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic

  • Observed Band(KD):

    27

  • Background:

    hydroxysteroid 17-beta dehydrogenase 10(HSD17B10) Homo sapiens This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014],

  • Function:

    catalytic activity:(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH.,catalytic activity:(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.,disease:A chromosomal microduplication involving HSD17B10 and HUWE1 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.,disease:Defects in HSD17B10 are the cause of 2-methyl-3-hydroxybutyryl-

  • Subcellular Location:

    Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .

  • Expression:

    Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.

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Catalog Number

  • Amount:100ul
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ERAB Polyclonal Antibody | EnoGene Biotech Co. Ltd