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Epsin 1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71601

  • Amount:

    100ul

  • Molecular Weight:

    57575Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    Synthesized peptide derived from Epsin 1 . at AA range: 140-220

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of MOuse-brain cells using Epsin 1 Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    EPN1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Epsin-1

  • Human Gene Id:

    29924

  • Human Swiss Prot No:

    Q9Y6I3

  • Mouse Gene Id:

    13854

  • Mouse Swiss Prot No:

    Q80VP1

  • Rat Gene Id:

    117277

  • Rat Swiss Prot No:

    O88339

  • Specificity:

    Epsin 1 Polyclonal Antibody detects endogenous levels of Epsin 1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    EPN1; Epsin-1; EH domain-binding mitotic phosphoprotein; EPS-15-interacting protein 1

  • Observed Band(KD):

    85

  • Background:

    epsin 1(EPN1) Homo sapiens This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016],

  • Function:

    domain:The DPW repeat domain is involved in AP2A2 and clathrin binding.,domain:The NPF repeat domain is involved in EPS15 binding.,function:Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.,online information:The bubble's bend -Issue 42 of January 2004,PTM:Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.,PTM:Ubiquitinated.,similarity:Belongs to the epsin family.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,subcellular location:Associated with the cytoplasmic membrane

  • Subcellular Location:

    Cytoplasm . Cell membrane ; Peripheral membrane protein . Nucleus . Membrane, clathrin-coated pit . Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). .

  • Expression:

    Brain,Epithelium,Mammary gland,

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Catalog Number

  • Amount:100ul
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Epsin 1 Polyclonal Antibody | EnoGene Biotech Co. Ltd