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EphB4 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71587

  • Amount:

    100ul

  • Molecular Weight:

    108270(DA) Observed Band(KD)108

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human EPHB4. AA range:571-620

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of HY926 cells using EphB4 Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    EPHB4

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Ephrin type-B receptor 4

  • Human Gene Id:

    2050

  • Human Swiss Prot No:

    P54760

  • Mouse Gene Id:

    13846

  • Mouse Swiss Prot No:

    P54761

  • Specificity:

    EphB4 Polyclonal Antibody detects endogenous levels of EphB4 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    EPHB4; HTK; MYK1; TYRO11; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11

  • Background:

    EPH receptor B4(EPHB4) Homo sapiens Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-B family. Binds to ephrin-B2. May have a role in events mediating differentiation and development.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Abundantly expressed in placenta and in a range of primary tissues and malignant cell lines. Expressed in fetal, but not adult, brain, and in primitive and myeloid, but not lymphoid, hematopoietic cells.,

  • Subcellular Location:

    extracellular region,cytosol,plasma membrane,integral component of plasma membrane,extracellular exosome,

  • Expression:

    Epithelium,Ovary,Pancreas,Spleen,

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Catalog Number

  • Amount:100ul
  • Price:225$

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EphB4 Polyclonal Antibody | EnoGene Biotech Co. Ltd