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EphA1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71573Amount:
100ulApplications:
WB;IHC-p;IF(paraffin section)Reactivity:
Human;Rat;MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.Immunogen:
Synthetic Peptide of EphA1Source:
Polyclonal, Rabbit,IgG
- Western blot analysis of 1)Mouse Brain Tissue, 2)Hela, 3)Rat Brain Tissue with EphA1 Rabbit pAb diluted at 1:2,000.
Gene Name:
EPHA1Dilution:
WB 1:1000-2000, IHC 1:100-200Protein Name:
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)Human Gene Id:
2041Human Swiss Prot No:
P21709Mouse Swiss Prot No:
Q60750Specificity:
EphA1 protein(A222) detects endogenous levels of EphA1Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
EPHA1; EPH; EPHT; EPHT1; Ephrin type-A receptor 1; hEpha1; EPH tyrosine kinase; EPH tyrosine kinase 1; Erythropoietin-producing hepatoma receptor; Tyrosine-protein kinase receptor EPHObserved Band(KD):
110Background:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008],Function:
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family. Binds with a low affinity to ephrin-A1.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Overexpressed in several carcinomas.,Subcellular Location:
Cell membrane ; Single-pass type I membrane protein .Expression:
Overexpressed in several carcinomas.
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