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EP3 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71568Amount:
100ulMolecular Weight:
27678DaApplications:
WB;ELISAReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
Synthesized peptide derived from the N-terminal region of human Cdc42EP3.Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of K562 cells using Cdc42EP3 Polyclonal Antibody
Gene Name:
CDC42EP3Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.Protein Name:
Cdc42 effector protein 3Human Gene Id:
10602Human Swiss Prot No:
Q9UKI2Mouse Gene Id:
260409Mouse Swiss Prot No:
Q9CQC5Specificity:
Cdc42EP3 Polyclonal Antibody detects endogenous levels of Cdc42EP3 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CDC42EP3; BORG2; CEP3; Cdc42 effector protein 3; Binder of Rho GTPases 2; MSE55-related Cdc42-binding proteinObserved Band(KD):
26Background:
This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012],Function:
function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7.,tissue specificity:Highly expressed in the heart and weakly in the brain.,Subcellular Location:
Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton .Expression:
Highly expressed in the heart and weakly in the brain.
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