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ENX-2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71563

  • Amount:

    100ul

  • Molecular Weight:

    85271Da

  • Applications:

    WB;IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Monkey

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human EZH1. AA range:171-220

  • Source:

    Polyclonal, Rabbit,IgG

  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using EZH1 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Gene Name:

    EZH1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Histone-lysine N-methyltransferase EZH1

  • Human Gene Id:

    2145

  • Human Swiss Prot No:

    Q92800

  • Mouse Gene Id:

    14055

  • Mouse Swiss Prot No:

    P70351

  • Specificity:

    ENX-2 Polyclonal Antibody detects endogenous levels of ENX-2 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    EZH1; KIAA0388; Histone-lysine N-methyltransferase EZH1; ENX-2; Enhancer of zeste homolog 1

  • Observed Band(KD):

    85

  • Background:

    enhancer of zeste 1 polycomb repressive complex 2 subunit(EZH1) Homo sapiens EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009],

  • Function:

    catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,function:Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.,similarity:Belongs to the histone-lysine methyltransferase family. EZ subfamily.,similarity:Contains 1 SET domain.,s

  • Subcellular Location:

    Nucleus . Colocalizes with trimethylated 'Lys-27' of histone H3.

  • Expression:

    Brain,Hippocampus,Uterus,

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