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Endo180 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71556

  • Amount:

    100ul

  • Molecular Weight:

    166655Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from the Internal region of human MRC2. AA range:721-770

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of HeLa cells using Endo180 Polyclonal Antibody. Secondary antibody was diluted at 1:20000

  • Gene Name:

    MRC2

  • Dilution:

    Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    C-type mannose receptor 2

  • Human Gene Id:

    9902

  • Human Swiss Prot No:

    Q9UBG0

  • Mouse Gene Id:

    17534

  • Mouse Swiss Prot No:

    Q64449

  • Rat Gene Id:

    498011

  • Rat Swiss Prot No:

    Q4TU93

  • Specificity:

    Endo180 Polyclonal Antibody detects endogenous levels of Endo180 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MRC2; CLEC13E; ENDO180; KIAA0709; UPARAP; C-type mannose receptor 2; C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2Urokinase-type plasminogen activator receptor-associated protein; UPAR-associated protein; Urokinase receptor-associated protein; CD280

  • Observed Band(KD):

    170

  • Background:

    mannose receptor C type 2(MRC2) Homo sapiens This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012],

  • Function:

    domain:C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.,domain:Fibronectin type-II domain mediates collagen-binding.,domain:Ricin B-type lectin domain contacts with the second C-type lectin domain.,function:May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as

  • Subcellular Location:

    Membrane; Single-pass type I membrane protein.

  • Expression:

    Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.

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Catalog Number

  • Amount:100ul
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Endo180 Polyclonal Antibody | EnoGene Biotech Co. Ltd