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Elongin A1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71532

  • Amount:

    100ul

  • Molecular Weight:

    87230Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human TCEB3. AA range:131-180

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Elongin A1 Polyclonal Antibody

  • Gene Name:

    TCEB3

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Transcription elongation factor B polypeptide 3

  • Human Gene Id:

    6924

  • Human Swiss Prot No:

    Q14241

  • Mouse Gene Id:

    27224

  • Mouse Swiss Prot No:

    Q8CB77

  • Rat Swiss Prot No:

    Q63187

  • Specificity:

    Elongin A1 Polyclonal Antibody detects endogenous levels of Elongin A1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    TCEB3; MSTP059; Transcription elongation factor B polypeptide 3; Elongin 110 kDa subunit; Elongin-A; EloA; RNA polymerase II transcription factor SIII subunit A1; SIII p110

  • Observed Band(KD):

    87

  • Background:

    This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008],

  • Function:

    domain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].,function:SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).,similarity:Contains 1 F-box domain.,similarity:Contains 1 TFIIS N-terminal domain.,subunit:Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A.,

  • Subcellular Location:

    Nucleus .

  • Expression:

    Epithelium,Heart,Lung,Umbilical vein,

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