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eIF5A2 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71520Amount:
100ulApplications:
WB; ELISAReactivity:
Human; Mouse; RatPurification:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.Immunogen:
Synthesized peptide derived from human eIF5A/eIF5A2Source:
Polyclonal, Rabbit,IgG
- Western blot analysis of lysates from PC12 cells, primary antibody was diluted at 1:1000, 4°over night
Gene Name:
EIF5ADilution:
WB 1:500-2000, ELISA(peptide)1:5000-20000Protein Name:
eIF5A/eIF5A2Human Gene Id:
1984Human Swiss Prot No:
P63241/Q9GZV4Specificity:
This antibody detects endogenous levels of human eIF5A/eIF5A2Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1;eIF-5A1;Eukaryotic initiation factor 5A isoform 1;eIF-5A;Rev-binding factor;eIF-4D)Observed Band(KD):
17Function:
function:The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond.,PTM:eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).,similarity:Belongs to the eIF-5A family.,subunit:Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4.,tissue specificity:Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).,Subcellular Location:
Cytoplasm . Nucleus . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions (PubMed:19379712, PubMed:27306458). Nuclear export of hypusinated protein is mediated by XPO4 (PubMed:10944119, PubMed:27306458). .Expression:
Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
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