Product Information
Molecular Weight15297Da
Protein NameSH2 domain-containing protein 1B
Human Gene Id117157
Human Swiss Prot NoO14796
Mouse Swiss Prot NoO35324
SpecificityEAT-2 Polyclonal Antibody detects endogenous levels of EAT-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSH2D1B; EAT2; SH2 domain-containing protein 1B; EWS/FLI1-activated transcript 2; EAT-2
Functionfunction:Plays a role in controlling signal transduction through at least four receptors, CD84, CD150, CD229 and CD244, expressed on the surface of professional antigen-presenting cells.,similarity:Contains 1 SH2 domain.,subunit:Binds to the phosphorylated receptors CD84, CD150, CD229 and CD244. Does not bind to non-phosphorylated CD150.,
Subcellular Locationintracellular,cytosol,
ExpressionLeukocyte,Lung,Spleen,
BackgroundSH2 domain containing 1B(SH2D1B) Homo sapiens By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008],