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DUS2L Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71422

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human DUS2L. AA range:421-470

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    DUS2L

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Western blot analysis of lysates from RAW264.7 cells, using DUS2L Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    dihydrouridine synthase 2(DUS2) Homo sapiens This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012],

  • Protein Name:

    tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

  • Human Gene Id:

    54920

  • Human Swiss Prot No:

    Q9NX74

  • Mouse Gene Id:

    66369

  • Mouse Swiss Prot No:

    Q9D7B1

  • Specificity:

    DUS2L Polyclonal Antibody detects endogenous levels of DUS2L protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    DUS2L; DUS2; tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Up-regulated in lung cancer protein 8; URLC8; tRNA-dihydrouridine synthase 2-like; hDUS2

  • MolecularWeight(Da):

    55050

  • Observed Band(KD):

    55

  • Function:

    cofactor:FAD.,function:Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.,similarity:Belongs to the dus family. Dus2 subfamily.,similarity:Contains 1 DRBM (double-stranded RNA-binding) domain.,subcellular location:Mainly at the endoplasmic reticulum.,subunit:Interacts with EPRS.,tissue specificity:Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).,

  • Subcellular Location:

    cytoplasm,mitochondrion,endoplasmic reticulum,cytosol,

  • Expression:

    B-cell,Colon,Skin,

  • Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using DUS2L Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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