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Dok-1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71394

  • Amount:

    100ul

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human p62 Dok. AA range:365-414

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    DOK

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using p62 Dok Antibody. The picture on the right is blocked with the synthesized peptide.

  • Protein Name:

    Docking protein 1

  • Human Gene Id:

    1796

  • Human Swiss Prot No:

    Q99704

  • Specificity:

    Dok-1 Polyclonal Antibody detects endogenous levels of Dok-1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    DOK1; Docking protein 1; Downstream of tyrosine kinase 1; p62(dok); pp62MolecularWeight: 52392Da

  • Observed Band(KD):

    52

  • Background:

    docking protein 1(DOK1) Homo sapiens The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016], Function: domain:The PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.,PTM:Constitutively tyrosine-phosphorylated.,PTM:Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.,similarity:Belongs to the DOK family. Type A subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:Interacts with ABL (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3.,tissue specificity:Expressed in pancreas, heart, leukocyte and spleen

  • Subcellular Location:

    nucleus,cytoplasm,cytosol,perinuclear region of cytoplasm,

  • Western blot analysis of lysates from K562 cells, treated with Starvation 24h, using p62 Dok Antibody. The lane on the right is blocked with the synthesized peptide.

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