E20- 71391
Datasheet
Catalog Number:
E20-71391Amount:
100ulReactivity:
Human,MousePurification:
. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human DOCK1. AA range:1661-1710Source:
Polyclonal, RabbitGene Name:
DOCK1Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
- Western blot analysis of lysates from HeLa cells, using DOCK1 Antibody. The lane on the right is blocked with the synthesized peptide.
Protein Name:
Dedicator of cytokinesis protein 1Human Gene Id:
1793Human Swiss Prot No:
Q14185Specificity:
DOCK 180 Polyclonal Antibody detects endogenous levels of DOCK 180 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
DOCK1; Dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOCK180MolecularWeight: 215376DaObserved Band(KD):
215Background:
dedicator of cytokinesis 1(DOCK1) Homo sapiens This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],Function:
. domain:The DHR-2 domain is necessary and sufficient for the GEF activity.,function:Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.,similarity:Belongs to the DOCK family.,similarity:Contains 1 DHR-1 (CZH-1) domain.,similarity:Contains 1DHR-2 (CZH-2) domain.,similarity:Contains 1 SH3 domain.,subcellular location:Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-triphosphate.,subunit:Interacts with the SH3domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1.,tissue specificity:Highly expressedSubcellularLocation:intracellular,nucleus,nucleoplasm,cytoplasm,cytosol,membrane,guanyl-nucleotide exchange factor complex,
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