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DNA pol λ Polyclonal Antibody
Human;Mouse;Rat
WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NamePOLL
Product Information
Protein NameDNA polymerase lambda
Human Gene Id27343
Human Swiss Prot NoQ9UGP5
Mouse Gene Id56626
Mouse Swiss Prot NoQ9QXE2
Rat Gene Id361767
Rat Swiss Prot NoQ5RKI3
SpecificityDNA pol λ Polyclonal Antibody detects endogenous levels of DNA pol λ protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePOLL; DNA polymerase lambda; Pol Lambda; DNA polymerase beta-2; Pol beta2; DNA polymerase kappa
Molecular Weight63482Da
Observed Band(KD)63
Functioncatalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Manganese.,function:Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA polymerase type-X family.,similarity:Contains 1 BRCT domain.,subunit:Binds PCNA.,tissue specificity:Expressed in a number of tissues. Abundant in testis.,
Subcellular LocationNucleus . Chromosome . Accumulates at sites of DNA damage. .
ExpressionExpressed in a number of tissues. Abundant in testis.
ImmunogenThe antiserum was produced against synthesized peptide derived from human DNA Polymerase lambda. AA range:451-500
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-713878-Conjugate. Price: $485 / Size: 100μl.
E20-713878-FITC$485 / 100μlE20-713878-Biotin$485 / 100μlE20-713878-HRP$485 / 100μlE20-713878-AP$485 / 100μlE20-713878-AF350$485 / 100μlE20-713878-AF405M$485 / 100μlE20-713878-AF488$485 / 100μlE20-713878-AF514$485 / 100μlE20-713878-AF532$485 / 100μlE20-713878-AF555$485 / 100μlE20-713878-AF568$485 / 100μlE20-713878-AF405S$485 / 100μlE20-713878-AF405L$485 / 100μlE20-713878-AF546$485 / 100μlE20-713878-AF594$485 / 100μlE20-713878-AF610$485 / 100μlE20-713878-AF635$485 / 100μlE20-713878-AF647$485 / 100μlE20-713878-AF680$485 / 100μlE20-713878-AF700$485 / 100μlE20-713878-AF750$485 / 100μlE20-713878-AF790$485 / 100μlE20-713878-APC$485 / 100μlE20-713878-PE$485 / 100μlE20-713878-Cy3$485 / 100μlE20-713878-Cy5$485 / 100μlE20-713878-Cy5.5$485 / 100μlE20-713878-Cy7$485 / 100μlE20-713878-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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