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DJ-1 Polyclonal Antibody
Human;Mouse;Rat
WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NamePARK7
Product Information
Protein NameProtein DJ-1
Human Gene Id11315
Human Swiss Prot NoQ99497
Mouse Gene Id57320
Mouse Swiss Prot NoQ99LX0
Rat Gene Id117287
Rat Swiss Prot NoO88767
SpecificityDJ-1 Polyclonal Antibody detects endogenous levels of DJ-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePARK7; Protein DJ-1; Oncogene DJ1; Parkinson disease protein 7
Molecular Weight19891Da
Observed Band(KD)20
Functiondisease:Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson disease 7 (PARK7) [MIM:606324, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins),
Subcellular LocationCell membrane ; Lipid-anchor . Cytoplasm . Nucleus . Membrane raft . Mitochondrion . Endoplasmic reticulum . Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745). Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation. .
ExpressionHighly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain (at protein level). Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Expressed by pancreatic islets at higher levels than surrounding exocrine tissues (PubMed:22611253).DJ-1 upregulates the Nrf2/GPX4 signal pathway to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia Sci Rep-Uk. 2022 Feb;12(1):1-16. WB,IHC Human 1:1000 Placenta
ImmunogenThe antiserum was produced against synthesized peptide derived from human PARK7. AA range:61-110
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThe product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008],
Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4 ℃ overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negative control (right) obtained from antibody was pre-absorbed by immunogen peptide.
Western blot analysis of lysates from HUVEC, JurKat, HeLa, COLO205, and 293 cells, using PARK7 Antibody. The lane on the right is blocked with the synthesized peptide.
Conjugated Antibody
This product is also available conjugated. Format: E20-713854-Conjugate. Price: $485 / Size: 100μl.
E20-713854-FITC$485 / 100μlE20-713854-Biotin$485 / 100μlE20-713854-HRP$485 / 100μlE20-713854-AP$485 / 100μlE20-713854-AF350$485 / 100μlE20-713854-AF405M$485 / 100μlE20-713854-AF488$485 / 100μlE20-713854-AF514$485 / 100μlE20-713854-AF532$485 / 100μlE20-713854-AF555$485 / 100μlE20-713854-AF568$485 / 100μlE20-713854-AF405S$485 / 100μlE20-713854-AF405L$485 / 100μlE20-713854-AF546$485 / 100μlE20-713854-AF594$485 / 100μlE20-713854-AF610$485 / 100μlE20-713854-AF635$485 / 100μlE20-713854-AF647$485 / 100μlE20-713854-AF680$485 / 100μlE20-713854-AF700$485 / 100μlE20-713854-AF750$485 / 100μlE20-713854-AF790$485 / 100μlE20-713854-APC$485 / 100μlE20-713854-PE$485 / 100μlE20-713854-Cy3$485 / 100μlE20-713854-Cy5$485 / 100μlE20-713854-Cy5.5$485 / 100μlE20-713854-Cy7$485 / 100μlE20-713854-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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