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Desmin Polyclonal Antibody

E20-713826DatasheetCOAMSDS
Human;Rat;Mouse;
WB;IHC-p;IF/ICC;ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

Gene NameDES

Product Information

Protein NameDesmin
Human Gene Id1674
Human Swiss Prot NoP17661
Mouse Gene Id13346
Mouse Swiss Prot NoP31001
Rat Gene Id64362
Rat Swiss Prot NoP48675
SpecificityDesmin Polyclonal Antibody detects endogenous levels of Desmin protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameDES; Desmin
Molecular Weight(Da):53536
Observed Band(KD)55
Functiondisease:Defects in DES are the cause of cardiomyopathy dilated type 1I (CMD1I) [MIM:604765]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,disease:Defects in DES are the cause of desmin-related cardio-skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM).,disease:Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome) [MIM:181400].
Subcellular LocationCytoplasm, myofibril, sarcomere, Z line . Cytoplasm . Cell membrane, sarcolemma . Nucleus . Localizes in the intercalated disks which occur at the Z line of cardiomyocytes (PubMed:24200904, PubMed:26724190). Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes (By similarity). .
ExpressionMuscle,Skeletal muscle,Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis. Nature Communications 2017 Apr 10 WB,IF Human,Mouse 1:1000 liver,SGC7901 cell-xenograft SGC7901 cell
ImmunogenThe antiserum was produced against synthesized peptide derived from human Desmin. AA range:421-470
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008],
regulates liver microenvironment to promote gastric cancer liver metastasis." Nature
regulates liver microenvironment to promote gastric cancer liver metastasis." Nature
dysregulated in diabetic nephropathy and involved in high glucose‐induced podocyte injury via its interplay with β‐catenin." Journal of cellular and
dysregulated in diabetic nephropathy and involved in high glucose‐induced podocyte injury via its interplay with β‐catenin." Journal of cellular and
Immunofluorescence analysis of Hela cell. 1,Desmin Polyclonal Antibody(green) was diluted at 1:200(4℃ overnight). 2, Goat Anti Rabbit Alexa Fluor 488 was diluted at 1:1000(room temperature, 50min). 3 DAPI(blue) 10min.
Immunofluorescence analysis of Hela cell. 1,Desmin Polyclonal Antibody(green) was diluted at 1:200(4℃ overnight). 2, Goat Anti Rabbit Alexa Fluor 488 was diluted at 1:1000(room temperature, 50min). 3 DAPI(blue) 10min.
Western Blot analysis of various cells using Desmin Polyclonal Antibody diluted at 1:2000.
Western Blot analysis of various cells using Desmin Polyclonal Antibody diluted at 1:2000.
📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-713826-Conjugate. Price: $485 / Size: 100μl.

E20-713826-FITC$485 / 100μlE20-713826-Biotin$485 / 100μlE20-713826-HRP$485 / 100μlE20-713826-AP$485 / 100μlE20-713826-AF350$485 / 100μlE20-713826-AF405M$485 / 100μlE20-713826-AF488$485 / 100μlE20-713826-AF514$485 / 100μlE20-713826-AF532$485 / 100μlE20-713826-AF555$485 / 100μlE20-713826-AF568$485 / 100μlE20-713826-AF405S$485 / 100μlE20-713826-AF405L$485 / 100μlE20-713826-AF546$485 / 100μlE20-713826-AF594$485 / 100μlE20-713826-AF610$485 / 100μlE20-713826-AF635$485 / 100μlE20-713826-AF647$485 / 100μlE20-713826-AF680$485 / 100μlE20-713826-AF700$485 / 100μlE20-713826-AF750$485 / 100μlE20-713826-AF790$485 / 100μlE20-713826-APC$485 / 100μlE20-713826-PE$485 / 100μlE20-713826-Cy3$485 / 100μlE20-713826-Cy5$485 / 100μlE20-713826-Cy5.5$485 / 100μlE20-713826-Cy7$485 / 100μlE20-713826-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.

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