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DNA pol ε A Polyclonal Antibody
Datasheet
Catalog Number:
E20-71374Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human POLE1. AA range:1261-1310Source:
Polyclonal, RabbitGene Name:
POLEDilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using POLE1 Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
DNA polymerase epsilon, catalytic subunit(POLE) Homo sapiens This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013],Protein Name:
DNA polymerase epsilon catalytic subunit AHuman Gene Id:
5426Human Swiss Prot No:
Q07864Mouse Swiss Prot No:
Q9WVF7Specificity:
DNA pol ε A Polyclonal Antibody detects endogenous levels of DNA pol ε A protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
POLE; POLE1; DNA polymerase epsilon catalytic subunit A; DNA polymerase II subunit AMolecularWeight(Da):
261518Function:
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,domain:The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme.,function:Participates in DNA repair and in chromosomal DNA replication.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA polymerase type-B family.,subunit:Consists of two subunits (258 kDa and 55 kDa). Interacts with RAD17 and TOPBP1.,Subcellular Location:
nucleus,nucleoplasm,plasma membrane,epsilon DNA polymerase complex,Expression:
Aorta endothelial cell,Colon,Kidney,Lung,T-cell,Testis,
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Catalog Number
- Amount:100ul
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