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DNA pol ε 4 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71373Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human POLE4. AA range:61-110Source:
Polyclonal, RabbitGene Name:
POLE4Dilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using POLE4 Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
DNA polymerase epsilon 4, accessory subunit(POLE4) Homo sapiens POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004],Protein Name:
DNA polymerase epsilon subunit 4Human Gene Id:
56655Human Swiss Prot No:
Q9NR33Specificity:
DNA pol ε 4 Polyclonal Antibody detects endogenous levels of DNA pol ε 4 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
POLE4; DNA polymerase epsilon subunit 4; DNA polymerase II subunit 4; DNA polymerase epsilon subunit p12MolecularWeight(Da):
12209Observed Band(KD):
12Function:
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,function:May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subunit:Consists of four subunits: POLE1, POLE2, POLE3 and POLE4. Interacts with POLE3. When bound to POLE3, it can associate with polymerase epsilon p261 and p59 and form a complex.,Subcellular Location:
nucleus,Ada2/Gcn5/Ada3 transcription activator complex,epsilon DNA polymerase complex,Expression:
Cervix carcinoma,Skin,
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