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DNA pol δ cat Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71371

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human POLD1. AA range:1051-1100

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    POLD1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

  • Western blot analysis of lysates from K562 cells, using POLD1 Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    DNA polymerase delta 1, catalytic subunit(POLD1) Homo sapiens This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012],

  • Protein Name:

    DNA polymerase delta catalytic subunit

  • Human Gene Id:

    5424

  • Human Swiss Prot No:

    P28340

  • Mouse Gene Id:

    18971

  • Mouse Swiss Prot No:

    P52431

  • Rat Gene Id:

    59294

  • Rat Swiss Prot No:

    O54747

  • Specificity:

    DNA pol δ cat Polyclonal Antibody detects endogenous levels of DNA pol δ cat protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    POLD1; POLD; DNA polymerase delta catalytic subunit; DNA polymerase subunit delta p125

  • MolecularWeight(Da):

    123631

  • Observed Band(KD):

    110 124

  • Function:

    catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,function:Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.,miscellaneous:In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.,similarity:Belongs to the DNA polymerase type-B family.,subunit:Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. The 125 kDa subunit contains the polymerase active site and most likely the active site for

  • Subcellular Location:

    nucleotide-excision repair complex,nuclear chromosome, telomeric region,nucleus,nucleoplasm,cytoplasm,membrane,aggresome,delta DNA polymerase complex,

  • Expression:

    Brain,Lymph,

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Catalog Number

  • Amount:100ul
  • Price:225$

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DNA pol δ cat Polyclonal Antibody | EnoGene Biotech Co. Ltd