DNA pol γ2 Polyclonal Antibody

Name: DNA pol γ2 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-71370
Price: 225 USD
Availability: InStock

E20-71370Cite ID: EN0051503Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight(Da):54911

Protein NameDNA polymerase subunit gamma-2 mitochondrial

Human Gene Id11232

Human Swiss Prot NoQ9UHN1

Mouse Swiss Prot NoQ9QZM2

SpecificityDNA pol γ2 Polyclonal Antibody detects endogenous levels of DNA pol γ2 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NamePOLG2; MTPOLB; DNA polymerase subunit gamma-2; mitochondrial; DNA polymerase gamma accessory 55 kDa subunit; p55; Mitochondrial DNA polymerase accessory subunit; MtPolB; PolG-beta

Functioncatalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,disease:Defects in POLG2 are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4 (PEOA4) [MIM:610131]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadis

Subcellular Locationmitochondrial chromosome,mitochondrion,mitochondrial matrix,mitochondrial nucleoid,extracellular exosome,

ExpressionCerebellum,Cervix,Ovary,,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human POLG2. AA range:291-340

Gene NamePOLG2

DilutionImmunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

BackgroundDNA polymerase gamma 2, accessory subunit(POLG2) Homo sapiens This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-71370-Conjugate. Price: $485 / Size: 100μl.

E20-71370-FITC$485 / 100μlE20-71370-Biotin$485 / 100μlE20-71370-HRP$485 / 100μlE20-71370-AP$485 / 100μlE20-71370-AF350$485 / 100μlE20-71370-AF405M$485 / 100μlE20-71370-AF488$485 / 100μlE20-71370-AF514$485 / 100μlE20-71370-AF532$485 / 100μlE20-71370-AF555$485 / 100μlE20-71370-AF568$485 / 100μlE20-71370-AF405S$485 / 100μlE20-71370-AF405L$485 / 100μlE20-71370-AF546$485 / 100μlE20-71370-AF594$485 / 100μlE20-71370-AF610$485 / 100μlE20-71370-AF635$485 / 100μlE20-71370-AF647$485 / 100μlE20-71370-AF680$485 / 100μlE20-71370-AF700$485 / 100μlE20-71370-AF750$485 / 100μlE20-71370-AF790$485 / 100μlE20-71370-APC$485 / 100μlE20-71370-PE$485 / 100μlE20-71370-Cy3$485 / 100μlE20-71370-Cy5$485 / 100μlE20-71370-Cy5.5$485 / 100μlE20-71370-Cy7$485 / 100μlE20-71370-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.