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Defensin α3 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71323Amount:
100ulReactivity:
Human,Mouse,RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen..Immunogen:
The antiserum was produced against synthesized peptide derived from human Defensin alpha3. AA range:3-52Source:
Polyclonal, RabbitGene Name:
DEFA3Dilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
- Immunohistochemistry analysis of Defensin α3 antibody in paraffin-embedded human skeletal muscle tissue.
Protein Name:
Neutrophil defensin 3Human Gene Id:
1668Human Swiss Prot No:
P59666Specificity:
Defensin α3 Polyclonal Antibody detects endogenous levels of Defensin α3 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
DEFA3; DEF3; Neutrophil defensin 3; Defensin; alpha 3; HNP-3; HP-3; HP3MolecularWeight: 10245DaBackground:
defensin alpha 3(DEFA3) Homo sapiens Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014],Function:
function:Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.,similarity:Belongs to the alpha-defensin family.,subunit:Dimer.,Subcellular Location:
extracellular region,extracellular space,Golgi lumen,azurophil granule lumen,extracellular exosome
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